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TERT-BUTYL ALCOHOL (TERT-BUTANOL)†

Chemical Identification
CAS #	75-65-0
Formula	C₄H₁₀O
Synonyms	2-methyl-2-propanol; trimethylcarbinol; TBA

Physical Properties
Physical description	Colorless solid or liquid (above 77°F) with a camphor-like odor.
Boiling point	180°F	Molecular weight	74.14
Freezing point/melting point	78°F	Vapor pressure	42 mmHg at 77°F
Flash point	52°F	Vapor density	2.55
Specific gravity	0.78 at 78.8°F	Ionization potential	9.70 eV
Lower explosive limit (LEL)	2.4%	Upper explosive limit (UEL)	8%
NFPA health rating	2	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0462
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	1-10 L
Sampling flow rate (TWA)^*	0.01-0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1400 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device	Detector tube
Model/Type	Gastec 102L
Sampling information (see manufacturer instructions)	2 strokes, approx 0.05-1.2% range

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (300 mg/m³)	REL-TWA	100 ppm (300 mg/m³)	TLV-TWA		PEL-TWA	100 ppm (300 mg/m³)
PEL-STEL		REL-STEL	150 ppm (450 mg/m³)	TLV-STEL		PEL-STEL	150 ppm (450 mg/m³)
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: Visit the ACGIH TLV site for specific data		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	1600 ppm
Carcinogenic classifications: TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Tert-Butyl alcohol

NIOSH: Pocket Guide to Chemical Hazards - tert-Butyl alcohol

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - tert-Butanol. See annual publication for most recent information.

Last Updated Date : 04/05/2024

TRIFLUOROBROMOMETHANE†

Chemical Identification
CAS #	75-63-8
Formula	CBrF₃
Synonyms	bromotrifluoromethane; Fluorocarbon 1301; Freon13B1; Halocarbon 13B1; Halon1301; monobromotrifluoromethane; Refrigerant 13B1; trifluoromonobromomethane

Physical Properties
Physical description	Colorless, odorless gas.
Boiling point	-72°F	Molecular weight	148.9
Freezing point/melting point	-267°F	Vapor pressure	>1 atm
Flash point		Vapor density	5.14
Specific gravity		Ionization potential	11.78 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2500
Sampling group
Sampler/Sampling media	2 CSC tubes in series (first tube 400/200 mg, second tube 100/50 mg) [SKC 226-09 & SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	0.1-1 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1017 (partially validated)
Notes	Separate front and back tubes; ship on dry ice.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	1000 ppm (6100 mg/m³)	REL-TWA	1000 ppm (6100 mg/m³)	TLV-TWA	1000 ppm [1979]	PEL-TWA	1000 ppm (6100 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	40,000 ppm
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Bromotrifluoromethane

NIOSH: Pocket Guide to Chemical Hazards - Trifluorobromomethane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Trifluorobromomethane. See annual publication for most recent information.

Last Updated Date : 01/12/2023

DIFLUORODIBROMOMETHANE†

Chemical Identification
CAS #	75-61-6
Formula	CBr₂F₂
Synonyms	dibromodifluoromethane; Freon12B2; Halon1202

Physical Properties
Physical description	Colorless, heavy liquid or gas (above 76°F) with a characteristic odor.
Boiling point	76°F	Molecular weight	209.8
Freezing point/melting point	-231°F	Vapor pressure	620 mmHg
Flash point		Vapor density
Specific gravity	2.29 at 59°	Ionization potential	11.07 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0922
Sampling group
Sampler/Sampling media	2 CSC tubes (100/50 mg sections, 20/40 mesh) in series [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	2.5-10 L
Sampling flow rate (TWA)^*	0.01-0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1012 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device	Infrared spectrophotometer
Model/Type	Miran 1A & 1B
Sampling information (see manufacturer instructions)	0.04 ppm@9.2 µm

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (860 mg/m³)	REL-TWA	100 ppm (860 mg/m³)	TLV-TWA	100 ppm [1962]	PEL-TWA	100 ppm (860 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	2000 ppm
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Dibromodifluoromethane

NIOSH: Pocket Guide to Chemical Hazards - Difluorodibromomethane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Difluorodibromomethane. See annual publication for most recent information.

Last Updated Date : 12/28/2020

PROPYLENE OXIDE (1,2-EPOXYPROPANE)†

Chemical Identification
CAS #	75-56-9
Formula	C₃H₆O
Synonyms	1,2-epoxy propane; methyl ethylene oxide; methyloxirane; propene oxide; 1,2-propylene oxide

Physical Properties
Physical description	Colorless liquid with a benzene-like odor.
Boiling point	93.61°F	Molecular weight	58.08
Freezing point/melting point	-170°F	Vapor pressure	445 mmHg
Flash point	-35°F	Vapor density	2
Specific gravity	0.859 at 32°F	Ionization potential	9.81 eV
Lower explosive limit (LEL)	2.8%	Upper explosive limit (UEL)	37%
NFPA health rating	3	NFPA fire rating	4
NFPA reactivity rating	2	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2215
Sampling group
Sampler/Sampling media	Anasorb 747 (140/70 mg) [SKC 226-81A]
Sampling time^*
Sampling volume (TWA)^*	5 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 88 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device	Detector tube	Detector tube
Model/Type	Gastec 163	Matheson-Kitagawa 8014-163SA
Sampling information (see manufacturer instructions)	1 stroke, approx 0.03-3.9% range, uncertainty 25% for 0.06-1.3%, 16% for 1.3-3.9%	0.5 or 1 stroke, approx 0.05-5% range

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (240 mg/m³)	REL-TWA		TLV-TWA	2 ppm [2000]	PEL-TWA	2 ppm (4.75 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes: CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION (LOQ 8.4 ppm). See Appendix A, NIOSH Potential Occupational Carcinogens.		Notes: dermal sensitization (DSEN)		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	400 ppm
Carcinogenic classifications: IARC-2B, NIOSH-Ca, NTP-R, TLV-A3, EPA-B2		Notes: Ca
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3: 50 ppm/250 ppm/750 ppm

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Propylene oxide

NIOSH: Pocket Guide to Chemical Hazards - Propylene oxide

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Propylene oxide. See annual publication for most recent information.
Czene, K., et al.: Analysis of DNA and hemoglobin adducts and sister chromatid exchanges in a human population occupationally exposed to propylene oxide: a pilot study. Cancer Epidemiol. Biomarkers Prev. 11(3): 315-318, 2002.
Faller, T.H., Csanady, G.A., Kreuzer, P.E., Bauer, C.M. and Filser, J.G.: Kinetics of propylene oxide metabolism in microsomes and cytosol of different organs from mouse, rat, and humans. Toxicol. Appl. Pharmacol. 172(1): 62-74, 2001.
Pohanish, R.P. (editor): Propylene Oxide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1978-1980.

Last Updated Date : 01/11/2021

PROPYLENE IMINE†

Chemical Identification
CAS #	75-55-8
Formula	C₃H₇N
Synonyms	2-methylaziridine; 2-methylethyleneimine; propyleneimine; propylene imine (inhibited); propylenimine

Physical Properties
Physical description	Colorless, oily liquid with an ammonia-like odor.
Boiling point	152°F	Molecular weight	57.11
Freezing point/melting point	-85°F	Vapor pressure	112 mmHg
Flash point	25°F	Vapor density	2
Specific gravity	0.8039-0.807 at 77°F	Ionization potential	9.00 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating	3	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)
Sampling group
Sampler/Sampling media
Sampling time^*
Sampling volume (TWA)^*
Sampling flow rate (TWA)^*
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments
Method reference
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device	Detector tube
Model/Type	Gastec 180
Sampling information (see manufacturer instructions)	1-60 ppm range

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	2 ppm (5 mg/m³)	REL-TWA	2 ppm (5 mg/m³)	TLV-TWA	0.2 ppm [2008]	PEL-TWA	2 ppm (5 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL	0.4 ppm [2008]	PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes: CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A, NIOSH Potential Occupational Carcinogens.		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	100 ppm
Carcinogenic classifications: IARC-2B, NIOSH-Ca, NTP-R, TLV-A3		Notes: Ca
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Propyleneimine, stabilized

NIOSH: Pocket Guide to Chemical Hazards - Propylene imine

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Propyleneimine. See annual publication for most recent information.

Last Updated Date : 01/11/2021

IODINE†

Chemical Identification
CAS #	7553-56-2
Formula	I₂
Synonyms	iodine crystals; molecular iodine

Physical Properties
Physical description	Violet-black crystals with metallic luster and a sharp, characteristic odor.
Boiling point	365°F	Molecular weight	253.8
Freezing point/melting point	236°F	Vapor pressure	0.3 mmHg at 77°F
Flash point		Vapor density
Specific gravity	4.93	Ionization potential	9.31 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1515
Sampling group
Sampler/Sampling media	sampling glass tubes packed with 100 mg IABC front and 50 mg backup sections [SKC 226-80 or equivalent]
Sampling time^*	5 min
Sampling volume (TWA)^*	2-5 L
Sampling flow rate (TWA)^*	0.5 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	ISE
Method reference	OSHA ID-212 (fully validated)
Notes	Humidity at the sampling site needs to be assessed prior to the actual sampling. FOR OSHA CSHOs ONLY: If it is anticipated to be greater then 50%, please contact the SLTC for further instructions. Submit as separate sample. When the analysis of this compound is requested, analysis for Iodide is performed and reported as Iodine.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media	OSHA STAFF CONTACT SLTC FOR MEDIA
Bulk Method

On-Site Screening Techniques
Device	Detector tube	Detector tube
Model/Type	Gastec 9L	Gastec 80
Sampling information (see manufacturer instructions)	1-2 strokes, 0.04-12 ppm range, uncertainty 16% for 0.2-1.2 ppm, 8% for 1.2-12 ppm	1-4 strokes, approx 0.3-48 ppm range, uncertainty 16%

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA	0.01 ppm (inhalable fraction and vapor) [2007]	PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL	0.1 ppm (vapor fraction) [2007]	PEL-STEL
PEL-C	0.1 ppm (1 mg/m³)	REL-C	0.1 ppm (1 mg/m³)	TLV-C		PEL-C	0.1 ppm (1 mg/m³)
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	2 ppm
Carcinogenic classifications: TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3: 0.1 ppm/0.5 ppm/5 ppm

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Iodine

NIOSH: Pocket Guide to Chemical Hazards - Iodine

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Iodine and Iodides. See annual publication for most recent information.
International Chemical Safety Cards (WHO/IPCS/ILO): Iodine.
Backer, H. and Hallowell, J.: Use of iodine for water disinfection: iodine toxicity and maximum recommended dose. Environ. Health Perspect. 108(8): 679-684, 2000.
Pohanish, R.P. (editor): Iodine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1305-1306.

Last Updated Date : 01/29/2021

NITROMETHANE†

Chemical Identification
CAS #	75-52-5
Formula	CH₃NO₂
Synonyms	nitrocarbol

Physical Properties
Physical description	Colorless, oily liquid with a disagreeable odor.
Boiling point	214°F	Molecular weight	61.04
Freezing point/melting point	-20°F	Vapor pressure	28 mmHg
Flash point	95°F	Vapor density	2.11
Specific gravity	1.139	Ionization potential	11.08 eV
Lower explosive limit (LEL)	7.3%	Upper explosive limit (UEL)
NFPA health rating	2	NFPA fire rating	3
NFPA reactivity rating	4	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1920
Sampling group
Sampler/Sampling media	Chromosorb® 106 (600/300 mg) [SKC 226-111A]
Sampling time^*
Sampling volume (TWA)^*	1.2-3 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC
Method reference	NIOSH 2527 (fully validated)
Notes	Separate front and back sorbent sections
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (250 mg/m³)	REL-TWA		TLV-TWA	20 ppm [1997]	PEL-TWA	2 ppm (5 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes: See Appendix D - Substances with No Established RELs.		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	750 ppm
Carcinogenic classifications: TLV-A3, IARC-2B, NTP-R		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Nitromethane

NIOSH: Pocket Guide to Chemical Hazards - Nitromethane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Nitromethane. See annual publication for most recent information.
Page, E.H., Pajeau, A.K., Arnold, T.C., Fincher, A.R. and Goddard, M.J.: Peripheral neuropathy in workers exposed to nitromethane. Am. J. Ind. Med. 40(1): 107-113, 2001.
Pohanish, R.P. (editor): Nitromethane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1721-1722.
Webb, K.G. and Fowler, J.F., Jr.: Occupational allergic dermatitis to nitromethane. Am. J. Contact Dermat. 13(4): 201-202, 2002.

Last Updated Date : 01/13/2023

TRIMETHYLAMINE

Chemical Identification
CAS #	75-50-3
Formula	C₃H₉N
Synonyms	N,N-dimethylmethanamine; TMA [Note: May be used in an aqueous solution (typically 25%, 30%, or 40% TMA.]

Physical Properties
Physical description	Colorless gas with a fishy, amine odor.
Boiling point	37.2°F	Molecular weight	59.11
Freezing point/melting point	-179°F	Vapor pressure	1454 mmHg at 70°F
Flash point		Vapor density	2.09
Specific gravity	0.633 at 68°F	Ionization potential
Lower explosive limit (LEL)	2.0%	Upper explosive limit (UEL)	11.6%
NFPA health rating	3	NFPA fire rating	4
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	T127
Sampling group
Sampler/Sampling media	XAD-7 tube (80/40 mg) coated with phosphoric acid [SKC 226-98]
Sampling time^*	100 min
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA PV2060 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	10 ppm (24 mg/m³)	TLV-TWA	5 ppm [2012]	PEL-TWA	5 ppm (12 mg/m³)
PEL-STEL		REL-STEL	15 ppm (36 mg/m³)	TLV-STEL	15 ppm [2012]	PEL-STEL	15 ppm (36 mg/m³)
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	N	Skin notation	N
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3: 0.1/100 ppm/500 ppm

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Trimethylamine, anhydrous

NIOSH: Pocket Guide to Chemical Hazards - Trimethylamine

Literature References

NOAA: CAMEO Chemicals - Trimethylamine, aqueous solution.
ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Trimethylamine. See annual publication for most recent information.
Cashman, J.R., et al.: Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria. Curr. Drug Metab. 4(2): 151-170, 2003.
Amoore, J.E. and Forrester, L.J.: Specific anosmia to trimethylamine: the fishy primary odor. J. Chem. Ecology 2(1): 49-56, 1976.
Fluhr, J.W., et al.: Additive impairment of the barrier function and irritation by biogenic amines and sodium lauryl sulphate: a controlled in vivo tandem irritation study. Skin Pharmacol. Physiol. 18(2): 88-97, 2005.
Kenyon, S., et al.: The passage of trimethylamine across rat and human skin. Food Chem. Toxicol. 42(10): 1619-1628, 2004.
Mitchell, S.C. and Smith, R.L.: Trimethylamine and odorous sweat. J. Inherit. Metab. Dis. 26(4): 415-416, 2003.
Pohanish, R.P. (editor): Trimethylamine. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2275-2277.
Shimizu, M., Cashman, J.R. and Yamazaki, H.: Transient trimethylaminuria related to menstruation. BMC Med. Genet. 8: 2, 2007.

Last Updated Date : 07/13/2021

IODOFORM

Chemical Identification
CAS #	75-47-8
Formula	CHI₃
Synonyms	triiodomethane

Physical Properties
Physical description	Yellow to greenish-yellow powder or crystalline solid with a pungent, disagreeable odor.
Boiling point	424°F (sublimes)	Molecular weight	393.73
Freezing point/melting point	246°F	Vapor pressure
Flash point		Vapor density	4.1
Specific gravity	4.008	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)
Sampling group
Sampler/Sampling media
Sampling time^*
Sampling volume (TWA)^*
Sampling flow rate (TWA)^*
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments
Method reference
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	0.6 ppm (10 mg/m³)	TLV-TWA	0.001 ppm (inhalable fraction and vapor) [2021]	PEL-TWA	0.6 ppm (10 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	Y	Skin notation	N
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Iodoform

NIOSH: Pocket Guide to Chemical Hazards - Iodoform

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Iodoform. See also Notice of Intended Changes. See annual publication for most recent information.

Last Updated Date : 12/31/2020

CHLORODIFLUOROMETHANE

Chemical Identification
CAS #	75-45-6
Formula	CHClF₂
Synonyms	difluorochloromethane; Fluorocarbon-22, Freon22; Genetron22; monochlorodifluoromethane; Refrigerant 22

Physical Properties
Physical description	Colorless gas with a faint, sweet odor.
Boiling point	-41°F	Molecular weight	86.5
Freezing point/melting point	"-231°F"	Vapor pressure	9.4 atm
Flash point		Vapor density	3.11
Specific gravity	1.41 at -40°F	Ionization potential	12.45 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)
Sampling group
Sampler/Sampling media
Sampling time^*
Sampling volume (TWA)^*
Sampling flow rate (TWA)^*
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments
Method reference
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	1000 ppm (3500 mg/m³)	TLV-TWA	1000 ppm [1990]	PEL-TWA	1000 ppm (3500 mg/m³)
PEL-STEL		REL-STEL	1250 ppm (4375 mg/m³)	TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	N	Skin notation	N
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3, TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Chlorodifluoromethane

NIOSH: Pocket Guide to Chemical Hazards - Chlorodifluoromethane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Chlorodifluoromethane. See annual publication for most recent information.
U.S. EPA Integrated Risk Information System: Chlorodifluoromethane (CASRN 75-45-6).
Kintz, P., Baccino, E., Tracqui, A. and Mangin, P.: Headspace GC/MS testing for chlorodifluoromethane in two fatal cases. Forensic Sci. Int. 82(2): 171-175, 1996.
Kubota, T. and Miyata, A.: Acute inhalational exposure to chlorodifluoromethane (Freon-22): a report of 43 cases. Clin. Toxicol. (Phila.) 43(4): 305-308, 2005.
Nieuwenhuizen, M.S. and Groeneveld, F.R.: Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons. AIHAJ 61(4): 539-543, 2000.
Pohanish, R.P. (editor): Chlorodifluoromethane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 565-567.
Woollen, B. H., et al.: Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22). Int. Arch. Occup. Environ. Health 64(5): 383-387, 1992.

Last Updated Date : 01/31/2018

TERT-BUTYL ALCOHOL (TERT-BUTANOL)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

TRIFLUOROBROMOMETHANE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

DIFLUORODIBROMOMETHANE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

PROPYLENE OXIDE (1,2-EPOXYPROPANE)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

PROPYLENE IMINE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

IODINE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

NITROMETHANE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

TRIMETHYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

IODOFORM

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

CHLORODIFLUOROMETHANE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References