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N-NITROSOMETHYL-N-BUTYLAMINE

Chemical Identification
CAS #	7068-83-9
Formula	C₅H₁₂N₂O
Synonyms	NMBA; MBNA; butylamine, N-methyl-N-nitroso-; butanamine, N-methyl-N-nitroso-; methylbutylnitrosamine; methyl-n-butylnitrosamine; N-methyl-N-nitrosobutylamine; N-nitroso-n-butylmethylamine; nitrosomethyl-n-butylamine

Physical Properties
Physical description
Boiling point	193.6°C	Molecular weight	116.16
Freezing point/melting point		Vapor pressure	0.6 mmHg
Flash point	32.6°C	Vapor density	1
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating	4	NFPA fire rating	0
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N708
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	0.2-2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 38 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EO5425000.

Last Updated Date : 01/22/2024

N-NITROSOMETHYLETHYLAMINE

Chemical Identification
CAS #	10595-95-6
Formula	C₃H₈N₂O
Synonyms	NMEA; NEMA; ethylamine, N-Methyl-N-nitroso; ethylmethylnitrosamine; N,N-methylethylnitrosamine; N-methyl-N-nitrosoethylamine; N-nitrosoethylmethylamine; N-methyl-N-nitroso-ethanamine

Physical Properties
Physical description	Pale yellow oil.
Boiling point	170°C	Molecular weight	88.11
Freezing point/melting point		Vapor pressure
Flash point	76°C	Vapor density	0.945
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N709
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	0.2-2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 38 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method	Limit the amount of bulk submitted to 1 g or 1 mL.

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-2B		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KR9200000.

Last Updated Date : 01/22/2024

N-NITROSOETHYL-N-BUTYLAMINE

Chemical Identification
CAS #	4549-44-4
Formula	C₆H₁₄N₂O
Synonyms	NEBA; N-ethyl-N-nitrosobutylamine; butylamine, N-ethyl-N-nitroso-; butanamine, N-ethyl-N-nitroso-; ethyl-n-butylnitrosamine; N-nitroso-n-butylethylamine

Physical Properties
Physical description	Pale yellow oil.
Boiling point		Molecular weight	130.191
Freezing point/melting point		Vapor pressure	0.087 mmHg
Flash point	93°C	Vapor density	0.91
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N707
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*	0.2-2 L/min
Analytical method instruments	GC-TEA
Method reference	OSHA 38 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EO5075000.

Last Updated Date : 01/22/2024

N-NITROSODIPHENYLAMINE

Chemical Identification
CAS #	86-30-6
Formula	C₁₂H₁₀N₂O
Synonyms	NDPA; diphenyl nitrosamine; Redax; Vulcatard; NDFA

Physical Properties
Physical description	Yellow to brown or orange powder or flakes or a black solid.
Boiling point		Molecular weight	198.24
Freezing point/melting point	151.7°F	Vapor pressure
Flash point		Vapor density
Specific gravity	1.23	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N109
Sampling group
Sampler/Sampling media	Midget fritted glass bubbler (MFGB) containing 15 mL Isopropanol [Infrequently Requested Method - OSHA personnel Contact SLTC before sampling 801-233-4900]
Sampling time^*	250 min
Sampling volume (TWA)^*	250 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 23 (fully validated)
Notes	The samples must be protected from light during and after sampling. Wrap Bubbler with black tape to protect from light. Samples must be either stored in a freezer and shipped frozen or analyzed within 6 days after collection.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3, EPA-B2		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodiphenylamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodiphenylamine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JJ9800000.
U.S. EPA Integrated Risk Information System: N-Nitrosodiphenylamine (CASRN 86-30-6).
McGregor, D.: The genetic toxicology of N-nitrosodiphenylamine. Mutation Res. 317(3): 195-211, 1994.
Pohanish, R.P. (editor): N-Nitrosodiphenylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1733-1735.

Last Updated Date : 01/05/2021

N-NITROSODIISOPROPYLAMINE

Chemical Identification
CAS #	601-77-4
Formula	C₆H₁₄N₂O
Synonyms	NDiPA; diisopropylamine, N-nitroso

Physical Properties
Physical description	White to pale yellow solid.
Boiling point	194.5°C	Molecular weight	130.188
Freezing point/melting point	>300°C	Vapor pressure
Flash point		Vapor density
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N706
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	0.2-2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 38 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: IM4360000.

Last Updated Date : 01/22/2024

N-NITROSODIETHYLAMINE

Chemical Identification
CAS #	55-18-5
Formula	C₄H₁₀N₂O
Synonyms	NDEA; DENA; DEN; DANA; diethylnitrosamine; diethylnitroso-amine; N,N-diethylnitrosamine; ethylamine, N-nitrosdi; N-ethyl-N-nitroso-ethanamine; nitrosodiethylamine

Physical Properties
Physical description	Clear slightly yellow liquid.
Boiling point	351°F	Molecular weight	102.14
Freezing point/melting point		Vapor pressure	5.7 mmHg
Flash point	145°F	Vapor density
Specific gravity	0.9422	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1947
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	0.2-2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 27 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-2A, EPA-B2		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodiethylamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodiethylamine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: IA3500000.
California Department of Public Health (CDPH): NDMA and Other Nitrosamines - Drinking Water Issues.
U.S. EPA Integrated Risk Information System: N-Nitrosodiethylamine (CASRN 55-18-5).
Godoy, W., et al.: CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. Carcinogenesis 23(4): 611-616, 2002.
Ito, N., Tamano, S. and Shirai, T.: A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 94(1): 3-8, 2003.
Moennikes, O., et al.: A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice. Cancer Res. 64(14): 4707-4710, 2004.
No Author: N-Nitrosodiethylamine (CAS No. 55-18-5) . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Oury, B., Limasset, J.C. and Protois, J.C.: Assessment of exposure to carcinogenic N-nitrosamines in the rubber industry. Int. Arch. Occup. Environ. Health 70(4): 261-271, 1997.
Pohanish, R.P. (editor): N-Nitrosodiethylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1730-1731.
Sansone, E.B. and Keimig, S.D.: Potential occupational exposure associated with parenteral administration of N-nitrosodiethylamine to Macaca mulatta: evidence of post-injection release to the atmosphere. IARC Sci. Publ. 105: 226-229, 1991.
Su, T., Bao, Z., Zhang, Q.-Y., Smith, T.J., Hong, J.-Y. and Ding, X.: Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 60(18): 5074-5079, 2000.
Verna, L., Whysner, J. and Williams, G.M.: N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol. Ther. 71(1-2): 57-81, 1996.

Last Updated Date : 01/22/2024

N-NITROSODIETHANOLAMINE

Chemical Identification
CAS #	1116-54-7
Formula	C₄H₁₀N₂O₃
Synonyms	NDELA; DELNA; 2,2'-iminodi-N-nitrosoethanol; bis(β-hydroxyethyl)nitrosamine; nitrosoiminodiethanol; 2,2'-(nitrosoimino) bis[ethanol]; N-nitrosobis(2-hydroxyethyl)amine; NCI-C55583; diethylamine, 2,2'-dihydroxy-N-nitroso; diethanolnitrosamine

Physical Properties
Physical description	Yellow to dark brown very viscous liquid with no distinct odor.
Boiling point	237°F at 1.5 mmHg	Molecular weight	134.16
Freezing point/melting point		Vapor pressure
Flash point		Vapor density
Specific gravity	1.28	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0907
Sampling group
Sampler/Sampling media	GFF Gelman Type A (37 mm) in 3-piece cassette no backup pad [SKC 225-706]
Sampling time^*	240 min
Sampling volume (TWA)^*	480 L
Sampling flow rate (TWA)^*	2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 31 (fully validated)
Notes	Sample open-faced!! Store samples in freezer.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method	Limit the amount of bulk submitted to 1 g or 1 mL.

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-2B, EPA-B2		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodiethanolamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodiethanolamine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KL9550000.
U.S. EPA Integrated Risk Information System: N-Nitrosodiethanolamine (CASRN 1116-54-7).
Ducos, P. and Gaudin, R.: N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. Int. Arch. Occup. Environ. Health 76(8): 591-597, 2003.
Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U. and Oesch, F.: DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutat. Res. 342(1-2): 95-102, 1995.
Loeppky, R.N., Goelzer, P. and Chen, Y.: DNA adducts from N-nitrosodiethanolamine and related β-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem. Res. Toxicol. 15(4): 470-482, 2002.
No Author: N-Nitrosodiethanolamine . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.

Last Updated Date : 01/05/2021

N-NITROSODIAMYLAMINE

Chemical Identification
CAS #	13256-06-9
Formula	C₁₀H₂₂N₂O
Synonyms	NDAmA; di-n-pentylnitrosamine; di-n-amylnitrosamine; dipentylamine, N-nitroso-

Physical Properties
Physical description	Clear light yellow liquid.
Boiling point	295°F at 12 mmHg	Molecular weight	186.34
Freezing point/melting point		Vapor pressure
Flash point		Vapor density
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N705
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*	75 min
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	0.2-2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 38 (fully validated)
Notes	Store samples in freezer. This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodiamylamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodiamylamine

Literature References

Last Updated Date : 01/22/2024

N-NITROSOPYRROLIDINE

Chemical Identification
CAS #	930-55-2
Formula	C₄H₈N₂O
Synonyms	NO-Pyr; NPYR; 1-nitroso-pyrrolidine; N-N-Pyr

Physical Properties
Physical description	Yellow liquid.
Boiling point	417°F	Molecular weight	100.14
Freezing point/melting point		Vapor pressure
Flash point	181°F	Vapor density
Specific gravity	1.085	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1950
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*	75 min
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 27 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-2B, EPA-B2		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosopyrrolidine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosopyrrolidine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UY1575000.
U.S. EPA Integrated Risk Information System: N-Nitrosopyrrolidine (CASRN 930-55-2).
Hunt, E.J. and Shank, R.C.: Formation and persistence of a DNA adduct in rodents treated with N-nitrosopyrrolidine. Carcinogenesis 12(4): 571-575, 1991.
McCoy, G.D., DeMarco, G.J., Haxhiu, L., Roggero, E., Sudilovsky, E.C. and Sudilovsky, O.: Effect of acute administration of N-nitrosopyrrolidine to male Syrian golden hamsters. Cancer Lett. 79(2): 161-165, 1994.
No Author: N-Nitrosopyrrolidine . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Pohanish, R.P. (editor): N-Nitrosopyrrolidine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1743-1744.
Siddiqi, M.A., Tricker, A.R., Kumar, R., Fazili, Z. and Preussmann, R.: Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer-Kashmir, India. IARC Sci. Publ. (105): 210-213, 1991.
Wong, M. and Hecht, S.S.: A cyclic N7,C8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats. Chem. Res. Toxicol. 10(7): 772-778, 1997.
Wong, H.L., Murphy, S.E. and Hecht, S.S.: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 18(1): 61-69, 2005.

Last Updated Date : 01/22/2024

N-NITROSOPIPERIDINE

Chemical Identification
CAS #	100-75-4
Formula	C₅H₁₀N₂O
Synonyms	NPIP; NO-Pip; 1-nitrosopiperidine

Physical Properties
Physical description	Light yellow oil or liquid.
Boiling point	423°F at 721 mmHg	Molecular weight	114.17
Freezing point/melting point		Vapor pressure
Flash point		Vapor density
Specific gravity	1.0631 at 65.3°F	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1949
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*	75 min
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 27 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-2B		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosopiperidine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosopiperidine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TN2100000.
No Author: Nitrosamines, 15 Listings . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Levallois, P., et al.: Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption. Food Chem. Toxicol. 38(11): 1013-1019, (2000).
Pohanish, R.P. (editor): N-Nitrosopiperidine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, (2002), pp. 1741-1742.
Siddiqi, M.A., Tricker, A.R., Kumar, R., Fazili, Z. and Preussmann, R.: Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer-Kashmir, India. IARC Sci. Publ. (105): 210-213, (1991).
Wong, H.L., Murphy, S.E. and Hecht, S.S.: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 18(1): 61-69, (2005).

Last Updated Date : 01/22/2024

N-NITROSOMETHYL-N-BUTYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSOMETHYLETHYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSOETHYL-N-BUTYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSODIPHENYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSODIISOPROPYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSODIETHYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSODIETHANOLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSODIAMYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSOPYRROLIDINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSOPIPERIDINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References