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PHENANTHRENE†

Chemical Identification
CAS #	85-01-8
Formula	C₁₄H₁₀
Synonyms	coal tar pitch volatiles; phenanthrin

Physical Properties
Physical description	Colorless monoclinic crystals with a faint aromatic odor. Solutions exhibit a blue fluorescence.
Boiling point	642°F	Molecular weight	178.24
Freezing point/melting point	212°F	Vapor pressure	depends upon the specific compound
Flash point	340°F	Vapor density	6.14
Specific gravity	1.025	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating	1	NFPA fire rating	0
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2038
Sampling group
Sampler/Sampling media	Coal Tar Pitch Volatiles (CTPV) Sampling Filters and Cassette [SLTC109]
Sampling time^*	480 min
Sampling volume (TWA)^*	960 L
Sampling flow rate (TWA)^*	2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 58 (fully validated in conjunction with Coal Tar Pitch Volatiles and Coke Oven Emissions)
Notes	After sampling, filter must be transferred to a glass vial with a Teflon-lined cap. Sample must be protected from direct sunlight.
Special requirements	These media are prepared by SLTC as needed and are not available for immediate shipment. Please allow time for SLTC to prepare these media prior to sampling.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	0.2 mg/m³ as Coal tar pitch volatiles (benzene soluble fraction)	REL-TWA	0.1 mg/m³ (cyclohexane-extractable fraction)	TLV-TWA	0.2 mg/m³ (benzene-soluble aerosol) [1984]	PEL-TWA	0.2 mg/m³
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes: CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A, NIOSH Potential Occupational Carcinogens. See also Appendix C, Supplementary Exposure Limits.		Notes: BEI®		Notes: As Coal tar pitch volatiles, see footnote [i].
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3, EPA-D, TLV-A1, NIOSH-Ca		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Phenanthrene

NIOSH: Pocket Guide to Chemical Hazards - Coal tar pitch volatiles

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Coal tar pitch volatiles [65996-93-2], as benzene soluble aerosol. See annual publication for most recent information.
U.S. EPA Integrated Risk Information System. Phenanthrene (CASRN 85-01-8).
Campo, L., et al. Biological monitoring of exposure to polycyclic aromatic hydrocarbons by determination of unmetabolized compounds in urine. Toxicol. Lett. 162(2-3): 132-138, 2006.
Elovaara, E., Mikkola, J., Makela, M., Paldanious, B. and Priha, E. Assessment of soil remediation workers' exposure to polycyclic aromatic hydrocarbons (PAH): biomonitoring of naphthols, phenanthrols, and 1-hydroxypyrene in urine. Toxicol. Lett. 162(2-3): 158-163, 2006.
Hecht, S.S., Chen, M., Yagi, H., Jerina, D.M. and Carmella, S.G. r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation. Cancer Epidemiol. Biomarkers Prev. 12(12): 1501-1508, 2003.
Jacob, J. and Seidel, A. Biomonitoring of polycyclic aromatic hydrocarbons in human urine. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 778(1-2): 31-47, 2002.
Pohanish, R.P. (editor) Phenanthrene. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1817-1818.
Popp, W., et al. DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites in urine of coke oven workers. Occup. Environ. Med. 54(3): 176-183, 1997.
Rihs, H.P., et al. Occupational exposure to polycyclic aromatic hydrocarbons in German industries: association between exogenous exposure and urinary metabolites and its modulation by enzyme polymorphisms. Toxicol. Lett. 157(3): 241-255, 2005.

Last Updated Date : 01/29/2021

NORETHINDRONE

Chemical Identification
CAS #	68-22-4
Formula	C₂OH₂₆O₂
Synonyms	Micronor; 19-Norethisterone; Conceplan; Anouirle; 17-hydroxy-19-norpregn-4-en-20-yn-3-one; Norlutin; 17-hydroxy-19-nor-17-α-pregn-4-en-20-yn-3-one; NET; anhydrohydroxynorprogestrone

Physical Properties
Physical description	White crystalline powder.
Boiling point		Molecular weight	298.46
Freezing point/melting point	397.4°F	Vapor pressure	3.14x10-7 mmHg
Flash point		Vapor density
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N608
Sampling group
Sampler/Sampling media	Low-ash 37 mm PVC filter, 5 microns [SKC 225-802]
Sampling time^*	250 min
Sampling volume (TWA)^*	500 L
Sampling flow rate (TWA)^*	2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA PV2070 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

Last Updated Date : 01/07/2021

N-METHYL-2-PYRROLIDINONE

Chemical Identification
CAS #	872-50-4
Formula	C₅H₉NO
Synonyms	NMP; N-methylpyrrolidinone; N-methyl-2-pyrrolinone; 1-methyl-5-pyrrolidinone; methylpyrrolidone; N-methylpyrrolidone; composite constituent

Physical Properties
Physical description	A clear colorless liquid with a fish-like odor.
Boiling point	396°F	Molecular weight	99.13
Freezing point/melting point	-9°F	Vapor pressure
Flash point	204°F	Vapor density	3.4
Specific gravity	1.03	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating	2	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	M139
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*	50 min
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA PV2043 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA	1 ppm (4 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	Y
Notes: Not established		Notes: Not established		Notes: BEI® only		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Methyl-2-pyrrolidone

NIOSH: Pocket Guide to Chemical Hazards - N-Methyl-2-pyrrolidone

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - N-METHYL-2-PYRROLIDONE. See annual publication for most recent information.
Åkesson, B. and Jönsson, B.A.G.: Major metabolic pathway for N-methyl-2-pyrrolidone in humans. Drug Metab. Dispos. 25(2): 267-269, 1997.
Åkesson, B., Carnerup, M.A. and Jönsson, B.A.G.: Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone. Scan. J. Work Environ. Health 30(4): 306-312, 2004.
Jönsson, B.A.G. and Åkesson, B.: Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy-N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy-N-methylsuccinimide (2-HMSI), and biological monitoring using 2-HMSI as a biomarker. Int. Arch. Occup. Environ. Health 76(4): 267-274, 2003.
Leira, H.L., Tiltnes, A., Swendsen, K. and Vetlesen, L.: Irritant cutaneous reactions to N-methyl-2-pyrrolidone (NMP). Contact Dermatitis 27(3): 148-150, 1992.
Ligocka, D., Lison, D. and Haufroid, V.: Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism. Arch. Toxicol. 77(5): 261-266, 2003.
Malley, L.A., et al.: Chronic toxicity and oncogenicity of N-methylpyrrolidone (NMP) in rats and mice by dietary administration. Drug Chem. Toxicol. 24(4): 315-338, 2001.
Solomon, G.M., Morse, E.P., Garbo, M.J. and Milton, D.K.: Stillbirth after occupational exposure to N-methyl-2-pyrrolidone. A case report and review of the literature. J. Occup. Environ. Med. 38(7): 705-713, 1996.

Last Updated Date : 01/05/2021

METHOTREXATE

Chemical Identification
CAS #	59-05-2
Formula	C₂₀H₂₂N₈O₅
Synonyms	amethopterin; 4-amino-l0-methylfolic acid; 1-glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino))benzoyl; glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, L; methopterin; amethopterine; HDMTX; MTX; L-N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl) glutamic acid

Physical Properties
Physical description	Bright yellow-orange, odorless, crystalline powder.
Boiling point		Molecular weight	454.46
Freezing point/melting point	356-399°F	Vapor pressure
Flash point		Vapor density
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	M106
Sampling group
Sampler/Sampling media	OSHA versatile sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg) with GFF enclosed [SKC 226-30-16]
Sampling time^*	120 min
Sampling volume (TWA)^*	120 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA PV2146 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Methotrexate

NIOSH: Pocket Guide to Chemical Hazards - Methotrexate

Literature References

Bawle, E.V., Conard, J.V. and Weiss, L.: Adult and two children with fetal methotrexate syndrome. Teratology 57(2): 51-55, 1998.
Dastychová, E.: Allergic contact dermatitis in methotrexate manufacture. Contact Dermatitis 48(4): 226-227, 2003.
Deng, H., et al.: Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points. Mutagenesis 20(5): 351-357, 2005.
Izzedine, H., Launay-Vacher, V. Karie, S., Caramella, C., de Person, F. and Deray, G.: Is low-dose methotrexate nephrotoxic? Case report and review of the literature. Clin. Nephrol. 64(4): 315-319, 2005.
Kalantzis, A., Marshman, Z., Falconer, D.T., Morgan, P.R. and Odell E.W.: Oral effects of low-dose methotrexate treatment. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 100(1): 52-62, 2005.
Lateef, O., Shakoor, N. and Balk, R.A.: Methotrexate pulmonary toxicity. Expert Opin. Drug Saf. 4(4): 723-730, 2005.
Pohanish, R.P. (editor): Methotrexate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1504-1505.
Sessink, P.J., Friemel, N.S., Anzion, R.B. and Bos, R.P.: Biological and environmental monitoring of occupational exposure of pharmaceutical plant workers to methotrexate. Int. Arch. Occup. Environ. Health 65(6): 401-403, 1994.

Last Updated Date : 01/05/2021

METHIDATHION

Chemical Identification
CAS #	950-37-8
Formula	C₆H₁₁N₂O₄PS₃
Synonyms	Ultracide (TM); Supracide (TM); somonil; Fisons NC 2964; DMTP; ENT 27193

Physical Properties
Physical description	Colorless crystals.
Boiling point		Molecular weight	302.34
Freezing point/melting point	102-104°F	Vapor pressure	1x10-6 mmHg
Flash point		Vapor density
Specific gravity	1.495	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	M105
Sampling group
Sampler/Sampling media	OSHA versatile sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg) with GFF enclosed [SKC 226-30-16]
Sampling time^*	60 min
Sampling volume (TWA)^*	60 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-ECD
Method reference	OSHA PV2074 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Methidathion

NIOSH: Pocket Guide to Chemical Hazards - Methidathion

Literature References

Last Updated Date : 01/05/2021

MESTRANOL

Chemical Identification
CAS #	72-33-3
Formula	C₂₁H₂₆O₂
Synonyms	3-methoxy-17-⍺-19-norpregna-1,3,5(10)-trien-20-yn-17-ol; Compound 33355; 𝛿-MVE

Physical Properties
Physical description	Solid
Boiling point		Molecular weight	310.44
Freezing point/melting point	302.9	Vapor pressure	9.75x10-9
Flash point		Vapor density
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	M305
Sampling group
Sampler/Sampling media	Low-ash 37 mm PVC filter, 5 microns [SKC 225-802]
Sampling time^*	250 min
Sampling volume (TWA)^*	500 L
Sampling flow rate (TWA)^*	2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA PV2068 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

Last Updated Date : 01/05/2021

MANEB

Chemical Identification
CAS #	12427-38-2
Formula	C₄H₆MnN₂S₄
Synonyms	[ethylene bis(dithiocarbamate)]manganese; manzate

Physical Properties
Physical description	Yellow powder or crystalline solid.
Boiling point		Molecular weight	264.88
Freezing point/melting point	392°F	Vapor pressure	7.5x10-8 mmHg
Flash point		Vapor density	1.92
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	M177
Sampling group
Sampler/Sampling media	Mixed cellulose ester filter (MCEF) 0.8 micron (37 mm) and filter spacer with Na₂CO₃ impregnated backup pad, in a 3-piece cassette [SKC 225-9001]
Sampling time^*	250 min
Sampling volume (TWA)^*	500 L
Sampling flow rate (TWA)^*	2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 107 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Maneb

NIOSH: Pocket Guide to Chemical Hazards - Maneb

Literature References

Last Updated Date : 01/04/2021

PYRENE

Chemical Identification
CAS #	129-00-0
Formula	C₁₆H₁₀
Synonyms	benzo(d,e,f)phenanthrene

Physical Properties
Physical description	Colorless solid, solid and solutions have a slight blue fluorescence.
Boiling point	759°F	Molecular weight	202.26
Freezing point/melting point	313°F	Vapor pressure	depends upon the specific compound
Flash point		Vapor density
Specific gravity	1.27 at 73.4°F	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2217
Sampling group
Sampler/Sampling media	Coal Tar Pitch Volatiles (CTPV) Sampling Filters and Cassette [SLTC109]
Sampling time^*	480 min
Sampling volume (TWA)^*	960 L
Sampling flow rate (TWA)^*	2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 58 (fully validated in conjuction with Coal Tar Pitch Volatiles and Coke Oven Emissions)
Notes	OSHA personnel can obtain pre-cleaned filters, vials, and Teflon-lined caps from SLTC. After sampling, filter must be transferred to a glass vial with a PTFE-lined cap. Sample must be protected from direct sunlight.
Special requirements	These media are prepared by SLTC as needed and are not available for immediate shipment. Please allow time for SLTC to prepare these media prior to sampling.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established. Pyrene is a polynuclear aromatic hydrocarbon that OSHA has identified as one of a number of typical components of the benzene-soluble fraction of coal tar pitch volatiles. Other components include anthracene, benzo[a]pyrene, phenanthrene, acridine, and chrysene. Pyrene is characteristic of cold tar pitch volatiles (PEL is 0.2 mg/m³) and/or coke oven emissions (PEL is 0.15 mg/m³).		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Pyrene

NIOSH: Pocket Guide to Chemical Hazards - Pyrene

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UR2450000
U.S. EPA Integrated Risk Information System: Pyrene (CASRN 129-00-0).
Campo, L., et al.: Biological monitoring of exposure to polycyclic aromatic hydrocarbons by determination of unmetabolized compounds in urine. Toxicol. Lett. (Epub Oct. 20), 2005.
Huang, W., et al.: Comparison of 1-hydroxypyrene exposure in the US population with that in occupational exposure studies. Int. Arch. Occup. Environ. Health 77(7): 491-498, 2004.
Kim, Y.-D., et al.: Identification of cytochrome P450 isoforms involved in 1-hydroxylation of pyrene. Environ. Res. 94(3): 262-266, 2004.
Lai, C.-H., et al.: Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan. Arch. Environ. Health 59(2): 61-69, 2004.
McClean, M.D., et al.: Urinary 1-hydroxypyrene and polycyclic aromatic hydrocarbon exposure among asphalt paving workers. Ann. Occup. Hyg. 48(6): 565-578, 2004.
Pohanish, R.P. (editor): Pyrene. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1985-1986.
Ruzgyte, A., Bouchard, M. and Viau, C.: Development of a high-performance liquid chromatographic method for the simultaneous determination of pyrene-1,6- and 1,8-dione in animal and human urine. J. Anal. Toxicol. 29(6): 533-538, 2005.
Siwińska, E., Mielżyńska, D. and Kapka, L.: Association between urinary 1-hydroxypyrene and genotoxic effects in coke oven workers. Occup. Environ. Med. 61(3): e10 (7 pp.).

Last Updated Date : 01/29/2021

PERACETIC ACID

Chemical Identification
CAS #	79-21-0
Formula	C₂H₄O₃
Synonyms	peroxyacetic acid; acetic peroxide; monoperacetic acid; peroxoacetic acid

Physical Properties
Physical description	Colorless liquid with a strong, pungent, acrid odor.
Boiling point	221°F	Molecular weight	76.05
Freezing point/melting point	-22 to 32°F	Vapor pressure
Flash point	105°F (60% acetic acid solution)	Vapor density
Specific gravity	1.226 at 59°F	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating	3	NFPA fire rating	2
NFPA reactivity rating	4	NFPA special instruction	OX: Possesses oxidizing properties.
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	P230
Sampling group
Sampler/Sampling media	25-mm quartz fiber filter, coated with titanium oxysulfate, followed by an impinger containing methyl p-tolyl sulfide (MTS) and 4-chlorophenyl methyl sulfone in acetonitrile (ACN) [SLTC116]
Sampling time^*	15 min
Sampling volume (TWA)^*	15 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA PV2321 (partially validated)
Notes	The sampling method described in OSHA Method PV2321 will collect both particulate and vapor. However, any peracetic acid particulate collected on the pre-filter (H₂O₂ scrubber) will volatilize quickly, and the resultant vapor will be collected in the impinger solution.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL	0.4 ppm (inhalable fraction and vapor) [2013]	PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	N	Skin notation	NA
Notes: Not established		Notes: Not established		Notes:		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH	0.64 ppm (1.7 mg/m³)
Carcinogenic classifications: TLV-A4		Notes: existing IDLH under review by NIOSH
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Peracetic acid

NIOSH: Pocket Guide to Chemical Hazards - Peracetic acid

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Peracetic acid. See annual publication for most recent information.
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: SD8750000

Last Updated Date : 01/22/2021

N-NITROSO-N-PROPYL-N-BUTYLAMINE

Chemical Identification
CAS #	25413-64-3
Formula	C₇H₁₆N₂O
Synonyms	NPBA; 1-butanamine, N-nitroso-N-propyl; butylamine, N-nitroso-N-propyl; N-propyl-N-butylnitrosoamine

Physical Properties
Physical description
Boiling point		Molecular weight	144.21
Freezing point/melting point		Vapor pressure	0.0916 mmHg
Flash point	94.1°C	Vapor density	0.92
Specific gravity		Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	N805
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*	75 min
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	0.2-2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 38 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

Last Updated Date : 01/22/2024

PHENANTHRENE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

NORETHINDRONE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-METHYL-2-PYRROLIDINONE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

METHOTREXATE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

METHIDATHION

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

MESTRANOL

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

MANEB

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

PYRENE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

PERACETIC ACID

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-NITROSO-N-PROPYL-N-BUTYLAMINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References