ROTENONE | Occupational Safety and Health Administration

ROTENONE†

Chemical Identification
CAS #	83-79-4
Formula	C₂₃H₂₂O₆
Synonyms	1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methyl-ethenyl)-[1]benzopyrano [3,4-b]furo[2,3-h][1] benzopyran-6(6aH)-one

Physical Properties
Physical description	Colorless to red, odorless, crystalline solid.
Boiling point	410-428°F	Molecular weight	394.42
Freezing point/melting point	329-331°F	Vapor pressure	<0.00004 mmHg
Flash point		Vapor density
Specific gravity	1.27	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2228
Sampling group
Sampler/Sampling media	PTFE filter, 1 µm [SKC 225-2705]
Sampling time^*
Sampling volume (TWA)^*	8-400 L
Sampling flow rate (TWA)^*	1-4 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC-UV
Method reference	NIOSH 5007 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	5 mg/m³	REL-TWA	5 mg/m³	TLV-TWA	5 mg/m³ [1992]	PEL-TWA	5 mg/m³
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	2500 mg/m³
Carcinogenic classifications: TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Rotenone

NIOSH: Pocket Guide to Chemical Hazards - Rotenone

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Rotenone (commercial). See annual publication for most recent information.
Gao, H.M., Hong, J.S., Zhang, W. and Liu, B.: Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J. Neurosci. 23(4): 1228-1236, 2003.
Pohanish, R.P. (editor): Rotenone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2007-2009.
Sherer, T.B., et al.: Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23(34): 10756-10764, 2003.

Last Updated Date : 01/29/2021

ROTENONE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References